In December 1963, upon completion of his programme in Umudike, he was posted to the Agricultural Research station in Umudike as an Agricultural Assistant in Plant Breeding Unit where he worked from January 1964 to March 1965.
In April 1965, he was employed as a Library assistant by the Eastern Nigerian Library Board and served in Enugu before being transferred to Port-Harcourt where he worked at the Divisional Library while still entertaining thoughts of furthering his education. He wrote and passed the General Certificate of Education examination in January 1966. However, the advent of the Nigeria-Biafra war caused him to return to Abiriba in 1968 before joining the Biafra war effort like all Biafran youths as at that time. At the end of the war, he resumed his job with the East Central State Library Board but left shortly to assume a higher position with the Midwestern State Library Board in Benin City.
In August 1977 after he obtained a Bachelor’s in Banking and Finance, He landed a job with the Nigeria Customs Service as a Superintendent Collector Grande II. He underwent an initial senior officer’s course at the Customs Training School, Harvey Road, Yaba which equipped him for his distinguished career in the Nigeria Customs Service. His first posting was then to Rivers State Area Command in 1978 and eventually several other commands such as Gongola, Kaduna, Katsina, Federal Operations Unit, Bauchi and Cross River.
In 1993, He was promoted to the rank of Chief Superintendent of Customs and between 1996 and 1999, was an Instructor at the Customs Training College Ikeja. While serving as Instructor, he was named into a seven-men team of the ASYCUDA Implementation Committee which carried out the computerization of the Revenue Operations nationwide in the Nigeria Customs Service between 1997 and 2001.
January 1, 1999, he was promoted to Assistant Comptroller of Customs and made ASYCUDA Area Project Manager in Rivers Area III, Onne, Port-Harcourt. Another transfer took him to Tin Can Island Port in Lagos also as ASYCUDA Area Project Manager.
In March 2004, Kalu Agwu Nnanna was uplifted to Comptroller of Customs and appointed the Customs Area Controller, Tin Can Island Area Command. In September 2004, he was redeployed to Warri as the Customs Area Controller, Edo/Delta Command. He was redeployed again in September 2005 to NCS Headquarters as Comptroller (Finance& General Purpose Committee) of the Nigeria Customs Service Board.
After a distinguished career and meritorious service that spanned 29years in the Nigeria Customs Service, He retired with honour from the Federal Public Service having reached an enviable height as a Comptroller of Customs becoming the first Abiriba indigene to attain that status.