5/27/2020
Dear Jian,
祝贺你!!
你最崭新闪烁的生命科学理念今天 终于公布于世了。
Science Advances/Molecular Biology
Sci. Adv. 2020; 6 : eaaw5851 27 May 2020
A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals and C. elegans
Xiaoliang Wang1*†, Liquan Cai1*, Jeffrey X. Xie2, Xiaoyu Cui1, Jue Zhang1, Jiayan Wang1,Yiliang Chen3, Isabel Larre1, Joseph I. Shapiro4, Sandrine V. Pierre1, Dianqing Wu5,Guo-Zhang Zhu1,6, Zijian Xie1
Several signaling events have been recognized as essential for regulating cell lineage specification and organogenesis in animals. We find that the gain of an amino-terminal caveolin binding motif (CBM) in the subunit of the Na/K–adenosine triphosphatase (ATPase) (NKA) is required for the early stages of organogenesis in both mice and Caenorhabditis elegans. The evolutionary gain of the CBM occurred at the same time as the acquisition of the binding sites for Na+/K+. Loss of this CBM does not affect cell lineage specification or the initiation of organogenesis, but arrests further organ development. Mechanistically, this CBM is essential for the dynamic operation of Wnt and the timely up-regulation of transcriptional factors during organogenesis. These results indicate that the NKA was evolved as a dual functional protein that works in concert with Wnt as a hitherto unrecognized common mechanism to enable stem cell differentiation and organogenesis in multicellular organisms within the animal kingdom.
Submitted 7 January 2019
Accepted 2 March 2020
Published 27 May 2020
10.1126/sciadv.aaw5851
我相信,不久的将来,人们将会重新改写Na/K-ATPase对生命的意义,并应用它治疗疾病,造福于人类。
在为人类生命探讨的诗篇中,你终于可以画上一个完整的句号。
爱你,想你的Hong
Dear Jian,
Congratulations! Your newest and brightest concept of life science has finally come out.
(Sci. Adv. 2020; 6 : eaaw5851 27 May 2020)
I believe that in the near future, people will rewrite the meaning of Na/K-ATPase to life and apply it to treat diseases for the benefit of mankind. In the psalms for human life, you can finally draw a full stop.
Love and miss you
Hong